diff --git a/plugins/python-build/bin/python-build b/plugins/python-build/bin/python-build
index 69b617e3..60ace186 100755
--- a/plugins/python-build/bin/python-build
+++ b/plugins/python-build/bin/python-build
@@ -1826,8 +1826,13 @@ use_homebrew_zlib() {
 }
 
 use_xcode_sdk_zlib() {
+  local xcode_major;
   # If a custom compiler is used, including XCode SDK will likely break it
   [[ "${CC:-clang}" != "clang" || "$(command -v clang 2>/dev/null || true)" != "/usr/bin/clang" ]] && return 1
+  # The flags set by this function break the build in XCode 16 due to unknown changes from XCode 15
+  # For future-proofing, also disable it if we cannot determine the version
+  [[ $(xcodebuild -version) =~ ^Xcode\ ([[:digit:]]+) ]] && xcode_major="${BASH_REMATCH[1]}"
+  [[ -z $xcode_major || $xcode_major -ge 16 ]] && return 1
   local xc_sdk_path="$(xcrun --show-sdk-path 2>/dev/null || true)"
   if [ -d "$xc_sdk_path" ]; then
     echo "python-build: use zlib from xcode sdk"